Case Study: Supportive Diagnostic Procedures in A Canine Lymphoma Case at Hikari Veterinary Clinic
DOI:
https://doi.org/10.34145/ivas.v1i1.3853Keywords:
Diagnostic Procedure, Dog, Lymphoma, Supportive ExaminationAbstract
Lymphoma is one of the most common neoplastic diseases in dogs, typically characterized by the enlargement of lymph nodes due to malignant lymphocyte proliferation. This study aims to describe the sequence and use of supportive examinations for confirming lymphoma diagnosis in dogs at Hikari Vet Clinic. This study methods used a case study approach involving a 12-year-old male Mini Pinscher weighing 5.1 kg, diagnosed with lymphoma based on clinical symptoms and diagnostic tests. Data were collected through physical examination, hematology and blood chemistry analyses, ultrasonography, and radiography. The examinations were conducted from August to November 2024. The results showed that the patient had multiple enlarged lymph nodes, including the popliteal, submandibular, axillary, and inguinal lymph nodes. Hematology findings indicated leukocytosis and granulocytosis, accompanied by reduced red blood cell count, hemoglobin, hematocrit, and platelet levels, consistent with anemia. Blood chemistry analysis showed elevated levels of alkaline phosphatase (ALP) and glutamate pyruvate transaminase (GPT), while glucose and total cholesterol were decreased. Ultrasonography revealed enlarged, round lymph nodes with irregular margins and a hypoechoic appearance, and dorsoventral radiographs confirmed lymph node enlargement in the cervical region. This study concludes that hematology, biochemistry, ultrasound, and radiography examination procedures are very important to be carried out sequentially and correctly in order to establish a diagnosis.
Downloads
References
Amaliyah M, Tanuwijaya H, Wurijanto T. (2016). Rancangan bangun sistem informsi administrasi layanan pasien berbasis web pada klinik paradise surabaya. Jurnal Sistem Informasi Kaputama. 6(3).
Amanda AS. (2019). Penangan limfoma pada anjing golden retriever. Arshi Veterinary Letter. 3(2):21-22.
Arini FY, Handayati A, Astuti SSE, Anggraini AD. (2023). Uji komparasi hasil pemeriksaan hemoglobin menggunakan hematology analyzer dan hemoglobin meter pada pasien kadar normal dan abnormal rendah. Jurnal Penelitian Kesehatan SUARA FORIKES. 14(1):235-238.
Ashary A, Zelviani S, Fitriyanti, Ihsan. (2023). Analisis pengukuran dosis serap radiasi pada pemeriksaan foto thorax pasien pediatric di RSUD Djafar Harun Kolaka Utara. Jurnal Sains Fisika. 3(2):1-9.
Basariyadi A. (2016). Pengertian anamnesa, pemeriksaan fisik, pemeriksaan penunjang, diagnosis, prognosis, terapi dan tindakan medis. JSIKA. 6(3).
Belotta AF, Gomes MC, Rocha NS, Melchert A, Giuffrida R, Silva JP, Mamprim MJ. (2019). Sonography and sonoelastography in the detection of malignancy in supeficial lymph nodes of dogs. Journal of Veterinary Internal Medicine. 33(3):1403-1413.
Bergamaschi NA, Huber L, Ludewig E, Bohler A, Gumpenberger M, Hittmair MK, Strohmayer C, Folkertsma R, Rowan C. (2023). Association between clinical history in the radiographic request and diagnostic accuracy of thorax radiographs in dogs: A retrospective case-control study. Journal Vetereinary Internal Medicine. 37(6):53-59.
Borska P, Husnik R, Fictum P, Kehl A, Leva L, Faldyna M. (2018). Gastrointestinal B-lymphoblastic lymphoma in dog : cas report. Veterinary medicine. 63(1):40-49.
Carnicelli A, Williams AMM, Edwards DG. (2024). Paramedic education and training for the management of patients presenting with low-acuity clinical conditions: a scoping review. Healthcare. 12(2):176.
Colombe P, Béguin J, Benchekroun G, Le Roux D. (2022). Blood biomarkers for canine cancer, from human to veterinary oncology. Veterinary Comparative Oncoogyl. 20(4):767-777.
Comazzi S, Marcelli S, Cozzi M, Rizzi R, Finotello, Henriques J, Pastor J, Ponce F, Bley CR, rutgen BC, et al. (2018). Breed-associated risks for developing canine lymphoma network study. BMC Veterinary Research. 14(1):232.
Duplan AM, Chervier C, Finck M. (2023). Ultrasonographic findings of multicentric malignant lymphoma involving the urinary bladder in a dog: diagnosis and monitoring during chemotheraphy. Canadian Veterinary Journal. 64(9):844-848.
Fitriana L, Hardiyani T, Maulana MA. (2023). Uji kebocoran alat proteksi diri (Lead Apron) dengan menggunakan imaging plat (Ip) di instalasi radiologi klinik pratama Universitas Muhammadiyah Purwokerto. Jurnal Kesehatan Tambusai. 4(3):4194-4197.
Farizka I, Nandary D, Wijaya D. (2020). Panduan pelaksanaan pemeriksaan radiografi kedokteran gigi pada pasien anak. Jurnal Kedokteran Gigi Terpadu. 2(1):86-90
Green J. (2024). Civil emergencies: role of the vet in delivering veterinary care in a multi-agency environment. In Practice. 46:314-321.
Henriques J, Felisberto R, Constantino-Casas F, Cabeçadas J, Dobson J. (2021). Peripheral blood cell ratios as prognostic factors in canine diffuse large B-cell lymphoma treated with CHOP protocol. Veterinary Comparision Oncology. 19(2):242–252.
Iman BN, Mutiningrum FS, Rahmiati DU, Gunanti, Noviana D. (2022). Studi kasus neoplasia limpa dan hati anjing Shih Tzu dengan pemeriksaan klinis dan ultrasonografi. Jurnal Veteriner. 23(3):352- 359.
Kaseb H, Babiker HM. (2023). Hodgkin Lymphoma. Amerika Serikat: Stat Pearls Publishing.
Kumar K, Agrawal R, Pande N, Sharma S, Bhavna, Kumar H. (2018). Occurance, clinico-Haemato- biochemical and histopathological studies on mammary gland tumor in geriatric dogs. The Pharma Innovation Journal. 7(5):301-304.
Madsen T, Arnal A, Vittecoq M, Bernex F, Abadie J, Labrut S, Garcia D, Faugere D, Lemberger K, Beckmann C, et al. (2017). Cancer Prevalence and etiology in wild and captive animals. Ecology and Evolution of Cancer. 11–46.
Mahhiddine FY, You I, Park H, Kim MJ. (2022). Microbiome profile of dogs with stage IV multicentric lymphoma: a pilot study. Veterinary Science. 9(8):409.
Maini R, Nagalli S. (2023). Adenopathy. Treasure Island :Statpearls Publishing. Available from : https://www.nbci.nlm.nih.gov/books/NBK558918
Meomartino L, Greco A, Giancamillo MD, Brunetti A, Gnudi G. (2021). Imaging techniques in veterinary medicine. European Journa of Radiology Open. 8:382
Martini V, Marano G, Aresu L, Bonfati U, Boracchi P, Caniatti M, Cian F, Gambini M, Marconato L, Masserdotti C, et al. (2018). Performance of lymph node cytopathology in diagnosis andcharacterization of lymphoma in dogs. Journal of Veterinary Internal Medicine. 36:204-214.
Maslebu G, Adi K, Suryono. (2016). Using computer aided system to determine the maximum depth of visualization of B-mode diagnoctis ultrasound image. Journal of Physics Conference Series. 644(1):12-19.
Noviana D, Aliambar SH, Ulum MF, Siswandi R, Widyananta BJ, Soehartono RH, Soesatyoratih R, Zaenab S. (2018). Diagnosis Ultrasonografi pada Hewan Kecil. Bogor: PT Penerbit IPB Press
Oikonomidis IL, Milne E. (2023). Clinical enzymology of the dog and cat. Australian Veterinary Journal. 101: 465–478.
Paquin AR, Oyogoa E, McMurry HS, Kartika T, West M, Shatzel JJ. (2023). The diagnosis and management of suspected lymphoma in general practice. European Journal of Haematology. 110(1):3-13.
Purmono WA. (2020). Peran ultrasonografi toraks pada kasus kegawatdaruratan paru. Cermin Dunia Kedokteran. 47(9):706-712.
Reski MA, Sugianto I. (2022). Identifikasi kesalahan radiografi periapikal digital teknik bisecting: literature review. Sinnun Maxillofacial Journal. 04(2):104-112.
Rosida A. (2016). Pemeriksaan Laboratorium Penyakit Hati. Berkala Kedokteran. 12(1):123-131.
Sagome N, Risbon R, Burgess KE. (2018). Intestinal lymphoma in dogs : 84 case. Journal of the American Veterinary Medicine Association. 252(4):440-447.
Sarotama A, Arisoni A, Astawa IM. (2018). Penambahan modul usg dan modul fetal doppler pada telemedicine workstation. SNST.
Sauerbrei W, Taube SE, McShane LM, Cavenagh MM, Altman DG. (2018). Reporting Recommendations for Tumor Marker Prognostic Studies (REMARK): An Abridged Explanation and Elaboration. Journal of the National Cancer Institute. 110(8):803–811.
Sikumbang DJ, Panjaitan B, Syafruddin, Erwin, Masyitha D, Hamdan. (2018). Densitas radiografi tulang femur anjing lokal (Canis lupus familiaris) yang diovariohisterektomi. Jurnal Ilmiah Mahasiswa Veteriner. 2(3):268- 275.
Simarmata Y, Biru DMA, Restiati NI. (2021). Studi kasus: fibrosarcoma pada anjing. Jurnal Kajian Veteriner. 9(1):35-49.
Skor O, Bicanová L, Wolfesberger B, Fuchs-Baumgartinger A, Ruetgen B, Štěrbová M, Schwendenwein I, Kleiter M. (2021). Are B-symptoms more reliable prognostic indicators than substage in canine nodal diffuse large B-cell lymphoma. Veterinary Comparision Oncology. 19:201–208.
Sorenmo KU. (2020). Lymphoma in dogs: etiology, diagnosis, and management. VCNA, 50(3):489- 509.
Teodori S, Aste G, Tamburro R, Morselli-Labate AM, Simeoni F, Vignoli M. (2021). Computed tomography evaluation of normal canine abdominal lymph nodes: retrospective study of size and morphology according to body Weight and age in 45 Dogs. Veterinary Science. 8(3):44.
Vail M, Robinson S, Condon H. (2020). Recognition of oral potentially malignant disorders and transformation to oral cancer. Journal of the American Academy of Physician Assistant. 33(11):14-18
Wirahadikesuma I, Santoso K, Maheshwari H, Maddu A. (2020). Determining image opacity in broiler respiratory radiographic using imagej and anansel adam’s zone system. Jurnal Riset Veteriner Indonesia. 4(1):22-35.
Yang NY, Zheng HH, Yu C, Ye Y, Xie GH. (2024). Diagnosis of Canine Tumours and the Value of Combined Detection of VEGF, P53, SF and NLRP3 for the Early Diagnosis of Canine Mammary Carcinoma. Animals. 14(9).
Yohanda R. (2020). Metode studi kasus: upaya-upaya guru dalam meningkatkan motivasi belajar siswa sma negeri 14 pekanbaru. Kordinat. 14(1).
Yunisman Y, Salioso H, Febrianto S, Prayuda R, Mardatillah A. (2022). Analysis of quality of animal health services by veterinary medical and veterinary paramedic services in food security and agricultural agency of Rokan Hilir Regency. International Journal of Health Science. 6(S4):6-17.
Downloads
Published
How to Cite
Issue
Section
Citation Check
License
Copyright (c) 2026 Pradnya Calista, Matilde Surtini Bensa, Henny Endah Anggraeni
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
